Liposome NMN - molekyu ya NMN yotsekeredwa yokhala ndi mayamwidwe abwino kwambiri

NMN imatengedwa kuti ndiyo yabwino kwambiriNAD + kalambulabwalo m'thupi la munthu. Komabe, asayansi osamala amakhulupirira kuti kuyamwa kwa NMN kungakhalenso kochepa pamlingo wina. Pokhapokha powonjezera Mlingo waukulu wa NMN ndizotheka kusintha kothandiza.
Kuti izi zitheke, Bangtai adapanga liposome bwinoNMN, gulu loperekeza la NMN, ndipo linayamba kupanga zinthu zambiri.
Ndi chiyaniliposomes NMN ? Tiyeni tione kaye kuti liposomes ndi chiyani?
Liposomes ndi ma vesicles opangidwa ndi mamolekyu a phospholipid - mamolekyu omwewo omwe amapanga ma cell membranes.
Mamolekyu a Phospholipid amakhala ndi mutu wa hydrophilic phosphate ndi michira iwiri yamafuta a hydrophobic. Makhalidwewa amapanga liposomes chonyamulira zonse hydrophobic ndi hydrophilic mankhwala.

Chifukwa otsika mayamwidwe ndi bioavailability miyambo m`kamwa zakudya makapisozi, ndi encapsulation wa hydrophilic ndi hydrophobic zakudya mu liposomes amalola yogwira zosakaniza kulambalala chiwonongeko cha chapamimba dongosolo.
Kuti atulutse mamolekyu otetezedwa kumalo ochitirapo kanthu, lipid bilayer imalumikizana ndi ma bilayers ena (mwachitsanzo, ma cell membranes), kutulutsa zomwe zili mkati mwa liposomal mwachindunji ndikukhazikika m'maselo ndi minofu.
Kunena mwachidule, liposomes ali ngati galimoto yonyamula ndalama ya molekyulu, kuteteza "ndalama (mankhwala)" zomwe zili m'galimoto kuti zisabedwe panjira yopita kuchiwindi ndi ziwalo zina.
M'malo mwake, mankhwala a liposome akhala kale ndi nkhani zingapo zopambana. Anthu ena amagwiritsa ntchito liposomes kuti atseke Fisetin, ndipo bioavailability imachulukitsidwa mpaka nthawi 27; bioavailability wa liposomal vitamini B-12 chilinganizo ndi 3-5 nthawi apamwamba kuposa mapiritsi; liposomal berberine akhoza kuonjezera kufalitsidwa nthawi23-46.
Choncho, n'kofunika kubisaNMNmu liposomes?
Poyang'ana njira yotsimikiziridwa yochitirapo kanthu, NMN imadalira slc12a8 yonyamula katundu pa maselo ang'onoang'ono a m'mimba kuti alowe m'maselo, ndiyeno amawonjezera milingo ya NAD + mu ziwalo zosiyanasiyana ndi minofu ya thupi pamene magazi akuzungulira.
Komabe, NMN imawonongeka mosavuta pamene chinyezi ndi kutentha kufika pamtunda wina. Pakadali pano, ambiri a NMN pamsika ali mu mawonekedwe a makapisozi ndi mapiritsi. Mukatenga makapisozi a NMN kapena mapiritsi, ambiri a iwo amawonongeka m'mimba. Gawo laling'ono chabe la NMN limafika m'matumbo aang'ono, omwe ndi theka la zotsatira zake ndi kuyesetsa kawiri.
Pambuyo pa NMN kuzunguliridwa ndi liposomes, NMN ikhoza kutetezedwa kuti ifike kumalo omwe mukufuna.
Choyamba, liposomal NMN imatha kudutsa kuwonongeka kwa dongosolo la m'mimba, kulola kuti lilowe mwachindunji m'magazi ndikufikira ziwalo zosiyanasiyana za thupi.
Kachiwiri, liposomal NMN imatulutsa mamolekyu a NMN kudzera mu fusion ya membrane, yomwe imachedwetsa kuchotsedwa kwa mamolekyu a NMN ndikuwonjezera nthawi yawo yoyenda m'mitsempha yamagazi, kuchepetsa macrophages mu reticuloendothelial system (RES) kupita ku liposomal NMN. Digestion, ndikuwongolera kuchuluka kwa mamolekyu a NMN.
Kuonjezera apo, NMN yomwe imayikidwa mu liposomes imalepheretsa kagayidwe kake, ndipo mamolekyu a mankhwala amangogwira ntchito atatha kufika pamalo omwe akukhudzidwa ndikumasulidwa ku liposomes.
Pomaliza, liposomal NMN ndi njira yabwino yopewera kuwonongeka kwa NMN m'mimba.

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