Chiyambi cha NAD Pre-Cursor

NAD+ ndi coenzyme yofunikira, yomwe dzina lake lonse ndi nicotinamide adenine dinucleotide. Imapezeka kwambiri m'maselo ndipo imagwira nawo ntchito zambiri zofunikira pazachilengedwe. NAD+ imagwira ntchito yofunika kwambiri pazachilengedwe zambiri, kuphatikiza mphamvu zamagetsi, kupuma kwa ma cell, kukonza ma DNA, kusindikiza kwa majini, komanso kukalamba. Ikhoza kupeza kapena kumasula ma electron kuchokera kwa iwo kudzera muzochitika zosiyanasiyana za biocatalytic. Pochita izi, zochita zomwe NAD + zimatha kuyambitsa zikuphatikizapo redox, kuchepetsa carbonyl, acyl transfer, ndi zina zotero. Panthawiyi, NAD + imatsitsidwa kukhala NADH, potero ikupereka ma electron ndi ma hydrogen ions kuti azichita nawo ma enzyme ena. NAD+ yakopanso chidwi cha asayansi m'zaka zaposachedwa chifukwa imaganiziridwa kuti ikukhudzidwa ndi ukalamba. Kafukufuku wapeza kuti panthawi yokalamba, kuchuluka kwa NAD + m'maselo kumachepa, ndipo kuwonjezera NAD + kumatha kulimbikitsa kagayidwe kazakudya zama cell, kukonza kwa DNA ndikuchedwetsa kukalamba. Kuphatikiza apo, NAD + yapezekanso kuti ili ndi gawo lofunikira pakukonzanso kuwonongeka kwa DNA, apoptosis, kuyambitsa ma enzyme ndikuwongolera mawonekedwe a jini. Pakadali pano, anthu akufufuza mozama za NAD+ ndi gawo lake mu physiology ndi pathology, kuti adziwe zambiri za ntchito ndi ntchito za NAD+.