Sayansi | whitening zotsatira zodzoladzola zopangira - arbutin Gawo lachitatu

Natural zomera m'zigawo njira

Njirayi imagwiritsa ntchito masamba amtundu wa Ursi ngati zida zopangira, ndipo amagwiritsa ntchito organic zosungunulira m'zigawo, m'zigawo, mzati chromatography ndi kupatukana ndi kuyeretsa njira kupeza.arbutin kuchotsa. Pofika m’ma 1930, zinanenedwa kutiarbutin zili m'masamba a thanthwe kabichi. Kafukufuku wotsatira watsimikizira kuti arbutin amapezekanso m'masamba a mtengo wakuda wa mpunga, bilberry, bearberry ndi mtengo wa peyala. glycosides.

Popeza zomwe zili mu arbutin m'zomera ndizochepa kwambiri, njira yochotseramo imakhala yovuta, ndipo chiyero cha chotsitsacho sichiri chapamwamba, kotero ndi chitukuko cha njira zina zokonzekera, njira yochotsera zomera pang'onopang'ono yataya mwayi wake wampikisano.

Chomera minofu chikhalidwe

Njira ya chikhalidwe cha minofu ya zomera imagwiritsa ntchito mphamvu ya glycosylation ya maselo a zomera kuti isinthe hydroquinone kukhala arbutin. Poyerekeza ndi njira zochotsera zomera, mphamvu zopezera arbutin pogwiritsa ntchito njira za chikhalidwe cha zomera ndizokwera kwambiri. Mukamagwiritsa ntchito njirayi, kusankha njira yabwino yolumikizira minofu yamafuta ndikuzindikira zikhalidwe zoyenera ndikofunikira.

T Zopangira zomwe zimagwiritsidwa ntchito munjira ya chikhalidwe cha minyewa yazomera ndi zoyera, zosinthika ndizambiri, ndipo zomwe zimapangidwa sizikhala zowononga. Komabe, nthawi yopanga zinthu ndi yayitali, kulekanitsa ndi kuyeretsa kumakhala kovuta, ndipo chitukuko cha mafakitale sichikukula. Kumvetsetsanso njira ya kukula kwa maselo a zomera, kufotokozera zinthu zazikulu zomwe zimalimbikitsa kaphatikizidwe, kufupikitsa kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe ka kayendetsedwe kake.

Njira yopangira ma enzyme

The enzyme kaphatikizidwe njira makamaka amagwiritsa glycosyltransferase kapena glycosidase monga chothandizira kuti glycosyl kutengerapo ndi kubweza hydrolysis zimachitikira synthesize glycosides, ndiko kuti, arbutin analandira kuchokera hydroquinone ndi shuga pansi catalysis wa glycosidase.

Njira yophatikizira ma enzyme imakhala ndi njira yosavuta, kaphatikizidwe wapamwamba kwambiri, komanso chiyembekezo chakukula bwino. Ndi kafukufuku wozama pa njirayi m'zaka zaposachedwa, ma zymogen ochulukirapo apezeka, ndipo kuchuluka kwa kaphatikizidwe ka arbutin nakonso kukukulirakulira. Amakhulupirira kuti njira iyi idzakhala imodzi mwazofunikira pakufufuza kwa kaphatikizidwe ka arbutin m'tsogolomu. imodzi.

Kaphatikizidwe ka mankhwala

Nthawi zambiri, kaphatikizidwe ka mankhwala a arbutin amagwiritsa ntchito glucose ndi hydroquinone ngati zopangira. Awiriwo atatetezedwa moyenera, amakumana ndi glycosidation ndikuchotsa gulu loteteza. Njira yophatikizira mankhwala yakhala njira yofunika kwambiri pokonzekera arbutin chifukwa cha zabwino zake zopangira zinthu zopangidwa bwino komanso mtengo wotsika mtengo, ndipo yakwaniritsa kupanga mafakitale kunyumba ndi kunja.

Pakadali pano, ku China, shuga wa anhydrous amagwiritsidwa ntchito ngati zopangira, komansob -arbutin imapangidwa kudzera mu chitetezo cha acylation, catalytic condensation, ndi alkaline hydrolysis. Ndikukula kosalekeza kwaukadaulo wa kaphatikizidwe, m'zaka zaposachedwa, masitepe a kaphatikizidwe kanyumba ka arbutin asinthidwa pang'onopang'ono, kuchuluka kwa kaphatikizidwe kwasinthidwa mosalekeza, ndipo mtundu wafika pamlingo wapamwamba kwambiri padziko lonse lapansi. Komabe, chifukwa cha kusasunthika kosasinthika kwa zinthu mu kaphatikizidwe ka mankhwala, kafukufuku wozama kwambiri akufunikabe kuti apeze njira yabwino komanso yeniyeni yopangira mankhwala.a-arbutin.

Chitetezo cha arbutin

Chifukwa hydroquinone imakhala ndi mphamvu yoletsa tyrosinase, idagwiritsidwa ntchito popanga zodzoladzola zolimbana ndi freckle ndi zoyera kuti muchepetse kusinthika kwa khungu. Kafukufuku wamtsogolo adapeza kuti hydroquinone ili ndi chiopsezo choyambitsa matenda a exogenous ochronosis ndi vitiligo, komanso kulimbikitsa komanso carcinogenesis. Zowopsa zomwe zingatheke, zalembedwa ngati gawo loletsedwa la zodzoladzola m'dziko langa. Arbutin ndi tyrosinase inhibitor komanso m'malo mwa hydroquinone. Pansi pazikhalidwe monga kutsika kwa pH, kutentha kwambiri, ndi kuwala kwa ultraviolet, arbutin imatha kusinthidwa kukhala hydroquinone pogwira ntchito ndi tizilombo tating'onoting'ono tapakhungu kapena glucosidase, zomwe zimapangitsa kuti pakhale ngozi zakukhudzidwa, genotoxicity, kapena carcinogenesis. Chifukwa chake, kafukufuku wachitetezo cha arbutin nthawi zonse amakopa chidwi chamakampani.

Mu February 2023, SCCS idapereka lingaliro lake lomaliza pachitetezo chaa-arbutin ndib-arbutin mu zodzoladzola (SCCS/1642/22), ndi mfundo zotsatirazi

Foni yam'manja: 86 18691558819

Irene@xahealthway.com

www.xahealthway.com

https://healthway.en.alibaba.com/

Wechat: 18691558819

WhatsApp: 86 18691558819