Coenzyme Q10 ndiye coenzyme Q yokhayo m'thupi la munthu, yomwe imadziwikanso kuti ubiquinone. Coenzyme Q10 yatsimikiziridwa kuti ili ndi antioxidant, free radical scavenging, anti-chotupa komanso kupititsa patsogolo chitetezo chamunthu, potero imachepetsa kutopa ndikusintha mphamvu zolimbitsa thupi, komanso anti-kukalamba. Ndipo zotsatira zosiyanasiyana zaumoyo monga chitetezo cha mtima.
chimodzi,Physiological ntchito za coenzyme Q10
1. Free radical scavenging and antioxidant function (kuchedwetsa ukalamba ndikukongola)
Coenzyme Q10 imapezeka m'magawo awiri: ochepetsedwa ndi oxidized. Mwa iwo, yafupika coenzyme Q10 mosavuta oxidized ndipo angalepheretse peroxidation wa lipids ndi mapuloteni ndi scavenge ufulu ankafuna kusintha zinthu mopitirira. Chepetsani kupsinjika kwa okosijeni, zomwe ndi zotsatira zoyipa zomwe zimapangidwa ndi ma free radicals m'thupi ndipo ndizofunikira kwambiri zomwe zimayambitsa kukalamba ndi matenda. Coenzyme Q10 ndi antioxidant wamphamvu komanso free radical scavenger yomwe imatha kuchepetsa kuwonongeka komwe kumachitika chifukwa cha kupsinjika kwa okosijeni.Coenzyme Q10 amatha kusintha bioavailability wa khungu, kusintha khungu, kuonjezera ndende ya keratinocytes, kusintha antioxidant mphamvu ya maselo khungu, ziletsa kukalamba khungu, ndi kukwaniritsa achire zotsatira pa dermatitis, ziphuphu zakumaso, bedsores, zilonda zapakhungu ndi matenda ena apakhungu. Coenzyme Q10 imathanso kulimbikitsa mapangidwe a maselo a epithelial ndi kupangika kwa minofu ya granulation, kuteteza mapangidwe a zipsera, ndikulimbikitsa kukonza zipsera; ziletsa ntchito phosphotyrosinase, kuteteza mapangidwe melanin ndi mdima mawanga; kuchepetsa kuya kwa makwinya, kusintha khungu kuzimiririka; ndipo akhoza kuonjezera kuwonekera Kuchuluka kwa amino acid kumawonjezera chinyezi pakhungu; imakhala ndi zotsatira zabwino pakuwongolera kamvekedwe ka khungu losawoneka bwino, kuchepetsa makwinya, ndikubwezeretsanso khungu losalala, losalala komanso lonyowa.
2. Kupititsa patsogolo chitetezo chaumunthu ndi anti-chotupa
Kumayambiriro kwa 1970, kafukufuku wofunikira adanenanso kuti kutenga coenzyme Q10 mu mbewa kumatha kuonjezera zochitika za chitetezo cha mthupi popha mabakiteriya, kusintha mayankho a antibody, ndi kulimbikitsa kuchuluka kwa ma immunoglobulins ndi ma antibodies. Nikbakht et al. adaphunzira kuti pamene othamanga achimuna adatenga Coenzyme Q10 pambuyo pa mpikisano wotsatizana, chiwerengero cha neutrophils mu plasma yawo chinachepetsedwa kwambiri. Chifukwa chake, amakhulupirira kuti Coenzyme Q10 ndiyothandiza kuteteza chitetezo cha othamanga komanso kukulitsa chitetezo chathupi. Kwa anthu wamba, kumwa Coenzyme Q10 pakamwa pambuyo pogwira ntchito mopitirira muyeso kumatha kuchepetsa kutopa kwa thupi ndikuwonjezera nyonga yathupi.
Kafukufuku m'zaka zaposachedwa awonetsa kuti coenzyme Q10, monga chowonjezera chitetezo cha mthupi mwachindunji, imatha kukhala ndi gawo labwino pakuwongolera chitetezo chathupi komanso anti-chotupa, ndipo imakhala ndi zotsatira zina zachipatala pa khansa yapamwamba ya metastatic.
3. Limbitsani mphamvu za mtima ndikuwonjezera mphamvu zaubongo
Coenzyme Q10 ndi imodzi mwazinthu zofunika kwambiri m'thupi la munthu. Zomwe zili mu myocardium ndizokwera kwambiri. Ikasoŵa, imayambitsa kusagwira ntchito mokwanira kwa mtima, kuchititsa kuti magazi asayende bwino, kuchepetsa mphamvu yogwira ntchito ya mtima, ndipo pamapeto pake kumayambitsa matenda a mtima. Zotsatira zazikulu za coenzyme Q10 pa myocardium ndikulimbikitsa ma cell oxidative phosphorylation, kupititsa patsogolo mphamvu ya myocardial metabolism, kuchepetsa kuwonongeka kwa ischemia ku myocardium, kuonjezera kutulutsa kwa magazi a mtima, kusintha kusokonezeka kwakukulu ndi kukana arrhythmias, motero kuteteza myocardium. Kupititsa patsogolo ntchito ya mtima ndikupereka mphamvu zokwanira za myocardium. Kafukufuku wachipatala amasonyeza kuti oposa 75% odwala matenda a mtima asintha kwambiri chikhalidwe chawo atamwa Coenzyme Q10. Coenzyme Q10 ndi kagayidwe kachakudya kamene kamatha kuyambitsa kupuma kwa ma cell, kupereka mpweya wokwanira ndi mphamvu ku ma cardiomyocytes ndi ma cell aubongo, kusunga ma cell kukhala abwino komanso athanzi, motero amalepheretsa zochitika zamtima ndi cerebrovascular.
4. Kuwongolera lipids m'magazi
Ngakhale kutsitsa lipids m'magazi, ma statins amalepheretsanso kudziyimira pawokha kwa thupi kwa coenzyme Q10. Chifukwa chake, anthu omwe ali ndi lipids yayikulu m'magazi amayenera kumwa coenzyme Q10 akamamwa ma statins kuti achepetse lipid-kutsitsa. Coenzyme Q10 imatha kuchepetsa kuchuluka kwa lipoprotein otsika kwambiri omwe amavulaza thupi la munthu, kuteteza ma lipoprotein otsika kwambiri kuti asalowe mumpata wa cell endothelial, kuchepetsa mapangidwe a lipids pakhoma lamkati la mitsempha, ndikuletsa lipids kupanga atherosclerotic. zolembera pa intima ya mitsempha. , pamene kuonjezera ntchito ya mkulu-kachulukidwe lipoprotein, mwamsanga kuchotsa zinyalala, poizoni ndi zolengeza anapanga mkati khoma mitsempha ya magazi, kulamulira lipids magazi ndi kupewa mapangidwe atherosclerosis.
awiri, Chitetezo cha Coenzyme Q10
Thupi la munthu lilibe milingo yambiri ya Coenzyme Q10 pakubadwa, koma zomwe zili pamwambazi zimafika pachimake chazaka 20. Pambuyo pa zaka 25, kuthekera kopanga Coenzyme Q10 kumachepa pang'onopang'ono. Pamene msinkhu ukuwonjezeka, Coenzyme Q10 mu ziwalo zosiyanasiyana ndi minofu m'thupi pang'onopang'ono amachepetsa, ndipo Coenzyme Q10 mu mtima amachepetsa kwambiri. Pamene zomwe zili mu Coenzyme Q10 m'thupi la munthu zimachepa ndi 25% M'tsogolomu, matenda osiyanasiyana adzachitika, kotero kuti zowonjezera zowonjezera za Coenzyme Q10 ndizofunikira kwambiri. Chochititsa chidwi cha Coenzyme Q10 ndikuti sichiwotcha, si teratogenic ndipo sichikhala ndi zotsatirapo zoonekeratu, ndipo ndichotetezeka kwambiri kuti chigwiritsidwe ntchito kuchipatala. Coenzyme Q10, monga imodzi mwama coenzymes ofunika kwambiri m'thupi la munthu, imagwiritsidwa ntchito kwambiri pazachipatala.
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