Pofuna kufananiza zotsatira za NMNH ndi NMN, ofufuzawo anabaya PBS ndi 250 mg/kg ya NMN ndiNMNHmu C57BL/6N mbewa, motsatana, kenako ndikuyesa magazi motsatizana. Zotsatirazo zinasonyeza kuti NMNH inachulukitsa kwambiri NAD m'magazi, mpaka kufika pamlingo waukulu kuposa NMN. NAD idayesedwa pamatenda osonkhanitsidwa kudzera munjira yozungulira ma enzyme. Zotsatira zinasonyeza kuti NMNH inawonjezera milingo ya NAD m'magulu osiyanasiyana, ndipo zotsatira zake zinali zapamwamba kuposa za NMN. Zinali ndi zotsatira zoonekeratu pa chiwindi ndi impso, ndi chiwindi chowonjezeka ndi maulendo oposa 5 ndipo impso zikuwonjezeka nthawi zoposa 5. 2 nthawi.
NMNH idawonjezedwa panthawi ya reoxygenation, ndipo mawonekedwe a renal tubular injury marker KIM-1 adapezeka. Reoxygenation mu TEC inachititsa kuwonjezeka kwakukulu kwa mawu a KIM-1, omwe adatsika kwambiri pambuyo pa chithandizo cha NMNH, kusonyeza kuti kayendetsedwe ka mankhwalaNMNHamatha bwino komanso kuchepetsa kuwonongeka kwa maselo amtundu wa epithelial aimpso panthawi ya hypoxia ndi reoxygenation.
HealthwayNMNHkuwombera kwenikweni
Yang'anani pa bizinezi yosinthira kwa zaka zambiri
Yang'anirani mosamala kusankha kwa zipangizo ndikukhazikitsa maziko obzala
Kuyesa koyezetsa kokhazikika, kupanga kwapamwamba kwambiri
Epimedium Tingafinye, ndife akatswiri
Kupereka kwapamwamba, mwalandilidwa kupanga oda !!
