Makamaka amagwira ntchito za Spermidine ndi Spermidine trihydrochloridecan pakufufuza

Makamaka ntchito zaSpermidine ndiSpermidine trihydrochlorideakhoza mu kafukufuku

Spermidine [N-(3-aminopropyl) -1,4-diaminobutane] ndi triamine yodzaza ndi mizere yomwe nthawi zambiri imatchulidwa kuti ndi yapakatikati mu kaphatikizidwe ka spermine. Ili ndi mamolekyulu a C1H19N3 ndi molekyulu ya 145.25 g/mol ndipo ndi kamolekyu kakang'ono, kosungunuka m'madzi, komwe kamatha kulowa m'magulu achilengedwe. Zimachitika m'zamoyo zambiri, mosasamala kanthu za gulu la taxonomic.

Spermidine imatha kumangirira ku mitundu yosiyanasiyana ya mamolekyu, kuwapangitsa kukhala othandiza kwambiri. Amathandizira njira kuphatikiza kukula kwa ma cell, kukhazikika kwa DNA, kuchuluka kwa ma cell ndi apoptosis. Zikuwoneka kuti ma polyamines amagwira ntchito mofananamo ndi kukula kwa zinthu panthawi yamagulu a maselo. Ichi ndichifukwa chake spermidine ndi yofunika kuti minofu ikule bwino komanso kugwira ntchito.

1.Zotsutsana ndi zotupa za Spermidine za khansa ndi thanzi la mtima

Mu kafukufuku wa 2016, spermidine adapezeka kuti amasintha ukalamba ndikuwongolera magwiridwe antchito amtima mu mbewa zakale. Pamlingo wa chiwalo, kapangidwe ka mtima ndi magwiridwe antchito a mbewa okalamba amapatsidwa spermidine. Metabolism idapangidwanso bwino mu mbewa izi chifukwa chobwezeretsanso kapangidwe ka mitochondrial ndikugwira ntchito pambuyo pa spermidine supplementation.

2. Spermidinekuchita ngati anti-kukalamba zosakaniza

Pankhani ya moyo wautali, maphunziro ambiri a zinyama asonyeza kuti kutenga spermidine kumawonjezera moyo komanso kumalepheretsa chiwindi cha fibrosis ndi hepatocellular carcinoma. N'chimodzimodzinso ndi zakudya za polyamine. Palinso umboni wina wosonyeza kuti kumawonjezera kukana kupsinjika maganizo, ndipo kuchepa kwa zaka za spermidine kumathandizira chitukuko cha matenda okhudzana ndi ukalamba.

3.Spermidine trihydrochlorideakhoza rphunzitsani Chidziwitso Chochepa

Kafukufuku wofalitsidwa mu nyuzipepala ya Cell Reports mu 2021 amafotokoza kuti umuna wa zakudya umathandizira kuzindikira komanso kugwira ntchito kwa mitochondrial mu ntchentche ndi mbewa, komanso zimapereka chidziwitso chamunthu.