Kulankhulaberberine , aliyense angakhale wosazoloŵereka pang’ono, koma aliyense ayenera kudziŵa mwambi wodziŵika bwino wakuti: Munthu wosalankhula amadya coptis – sanganene ululu wake! Ndiko kulondola, chigawo chachikulu chowawa mu coptis ndi berberine, chomwe ndi berberine hydrochloride.
Berberine (BBR) ndi isoquinoline alkaloid - C20H19NO5 yotengedwa ku Coptis chinensis. Imapezeka muzomera za mibadwo 10 ndi mabanja 4 kuphatikiza Berberidaceae. Makhiristo achikasu ngati singano amatha kupangidwa kuchokera ku diethyl ether, ndi malo osungunuka a 145 ° C. Amasungunuka m'madzi ndipo samasungunuka mu benzene, diethyl ether ndi chloroform.
Kafukufuku wamakono wamankhwala watsimikizira kuti berberine ali ndi vuto lalikulu la mtima, anti-arrhythmia, kuchepetsa mafuta m'thupi, kufalikira kwa minofu yosalala, kupititsa patsogolo insulini kukana, anti-platelet, anti-yotupa ndi zotsatira zina. Choncho, zingakhale zothandiza mtima ndi mantha dongosolo matenda. Kukula kwake komanso kofunikira kogwiritsa ntchito kwachititsa chidwi kwambiri. Malinga ndi kafukufuku waposachedwa wachipatala, berberine imakhala ndi zotsatira zabwino popewa komanso kuchiza matenda oopsa, hyperlipidemia, shuga, arrhythmia, zotupa ndi matenda ena. Berberine hydrochloride yadziwika kwambiri pakuchepetsa lipids m'magazi. BBR imatha kuwongolera mawonekedwe a low-density lipoprotein receptor LDLR ndikulimbikitsa kuyamwa kwa mapuloteni a LDL ndi maselo a chiwindi. BBR imasinthidwa kukhala dihydroberberine (dhBBR) ndi nitroreductase ya m'matumbo amtundu wamatumbo a microbiota, ndikupangitsa kuti ilowe m'matumbo mosavuta. Pambuyo pa kuyamwa, imalowetsedwa mu BBR m'matumbo am'mimba ndikulowa m'magazi. Kupeza zotsatira za lipid-kutsitsa ndi hypoglycemic. BBR imathanso kupititsa patsogolo kagayidwe kazakudya. Kuwongolera pakamwa kwa BBR kumapangitsa kuti gut microbiota ipange butyrate, yomwe imalowa m'magazi ndikuchitapo kanthu pa SCFAs (mafupipafupi amafuta acids), kuchepetsa lipids m'magazi ndi shuga wamagazi.
BBR imatha kulimbikitsa kusinthika kwa ma cell a pancreatic islet ndipo imakhala ndi zabwino zambiri kuposa mankhwala ena oletsa matenda a shuga. Mayesero oyenerera azachipatala atsimikizira kuti berberine ikhoza kuletsa myocardial fibrosis mu makoswe a shuga; BBR imakhala ndi anti-platelet effect, imatha kuwonjezera ma nucleotide m'mapulateleti ndikuletsa kuphatikizika. Berberine pamodzi ndi ma statins amathandizira kwambiri kukhazikika kwa plasma trimethylamine oxidation mu matenda amtima komanso kuletsa mapangidwe a atherosulinosis.
Berberine waku China ndi njira yabwino yosinthira mankhwala a "statin". Popeza berberine ndi yotsika mtengo kangapo kuposa mankhwala a "statins", kupezeka kwa berberine kutsitsa-lipid-kutsitsa magazi kuli ndi phindu losayembekezereka popewa komanso kuchiza hyperlipidemia, shuga ndi matenda amtima.
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Nthawi yotumiza: Jan-08-2024
